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KMID : 0545120010110010167
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Journal of Microbiology and Biotechnology
2001 Volume.11 No. 1 p.167 ~ p.171
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A Preliminary Study on the Hypoglycemic Effect of the Exo-Polymers Produced by Five Different Medicinal Mushrooms
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Kim, Dong Hyun
Yang, Byung Keun/Jeong, Sang Chul/Hur, Nam Jung/Surajit Das/Yun, Jong Won/Choi, Jang Won
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Abstract
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The hypoglycemic effect of exo-polymers (EPs) produced from submerged mycelial cultures of five types of mushrooms on streptozotocin (STZ)-induced diabetic rats were investigated in this study. The five experimental groups were fed with EPs (50㎎/㎏ body weight) for 7 days. Significant reduction in plasma glucose, total cholesterol (TC), and triglyceride (TG) levels were observed in rats fed with Lentinus edodes and Cordyceps militaris EPs. Plasma glucose and TC were also reduced by administration of Phellinus linteus EPs, but the TG level was not changed significantly. The EPs of three mushroom species also demonstrated a marked reduction in the level of plasma glutamate-pyruvate transaminase (GPT). The result proves the hypoglycemic activity of EPs of three fungal groups in STZ-induced diabetic rats and indicates their potential in the control of diabetes mellitus.
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